Thirteen brings her one-night stand to the hospital after the woman has a seizure. However, the woman admits she slept with Thirteen just so she could get to House and have him diagnose her condition. Meanwhile, House continues to pay Lucas to spy on Wilson.
The team takes on the case of a deaf 14-year-old named Seth who collapsed after he started “hearing” explosions while competing in a wrestling match. When the team tries to test him for seizures, Seth loses vision in one eye, complicating House’s bunk theory of “Exploding Head Syndrome.” As his condition worsens, the team has an ethical disagreement about the patient and his mother’s adamant decision to forego cochlear implants to supplement his hearing. When the prospect of giving Seth the ability to hear for the first time in his life arises, House and the team are faced with a resounding decision. Meanwhile, House’s lack of sleep starts to play tricks on his mind, but he finds his insomnia may be a gift instead of a burden
House has to work fast when a woman comes in with a life-threatening case of insomnia. Meanwhile Cameron is angry at Foreman for stealing an article she worked on.
When a famous professional cyclist is brought in after collapsing during a race, House doesn’t want to treat him because he thinks he’s lying about doing drugs. But when the patient is forthcoming about taking all sorts of performance enhancers and blood-doping drugs, House is definitely intrigued. Cameron is upset the patient is a hero to kids when he is clearly cheating at his sport. She struggles with the ethical dilemma of patient confidentiality and considers going to the media. Meanwhile, House tries to disrupt Stacy and Mark’s relationship by attending a group therapy session with Mark.
The team deals with an organ donor whose organs prove fatal, and the two surviving patients. Meanwhile, House hires a private detective to spy on Wilson, but hears a few things about himself that he’d rather not.
An 18-year-old teenager is brought to the hospital after having a heart attack. House reviews the boy’s file and believes he has the diagnosis. He then turns the case into a game by sealing his opinion in an envelope and challenging Cameron, Foreman, and Chase to guess House’s diagnosis on their own. Meanwhile, Tritter’s actions against Wilson continue to strain the oncologist’s relationship with House and destroy his ability to practice medicine.
House insists he can handle things when Stacy, the woman he once loved, asks him to diagnose Mark, the man she married. When Mark’s tests come back normal yet symptoms show that his brain is dying, the puzzle may be one that even House can’t solve.
While Wilson worries about House’s emotional well-being, the team is blown away by his over-the-top demands. As House struggles to put his emotions aside and solve the case, Cuddy adds to his dilemma and offers Stacy a reason to stay.
House and his team deal with a bullied girl who collapses during her school’s Christmas program. Meanwhile, Foreman and Thirteen grow closer during the Huntington’s disease drug trials, House gives a patient a gift, the staff wonder who gave House a special gift, and Cuddy gets an unexpected gift.
When young wife Elyse falls ill with a rare disease she can’t possibly have, Dr. Cameron is very interested in the case – so much so that her interest convinces House to take the case, and the team struggles to save her and appease her very attentive husband, Ed. After Dr. House and Dr. Wilson treat a woman at the clinic with new breast implants, the idea that House’s new patient Elyse may have breast cancer is raised as a possible diagnosis. But that diagnosis fails to be the answer when Elyse lapses into a coma after starting treatment. House starts to suspect Elyse has contracted a rare sexually transmitted disease, but when Ed and Elyse are questioned individually, they each deny having an affair. To save their patient’s life, the team has to acknowledge that House is right: everybody lies.
The team takes on the case of Derrick, a 19-year-old college student who had a mysterious nose bleed during cheerleading practice, and discovers that his health issues are likely both physiological and psychological. Possibly suffering from schizophrenia, Derrick claims to hear his deceased brother’s voice in his head. Meanwhile, Foreman tries a different approach with House.
Science and faith are called into question when a patient is admitted to the hospital following his reenactment of the Crucifixion. Meanwhile, Taub questions his wife about her relationship with an infidelity support group member, and the team attends a co-worker’s wedding.
Under Cuddy’s pressure to choose his team, House gives the candidates a case of a former punk rock star who is a drug user. Whoever diagnoses the patient is going to have a future as a member of House’s team.
A mother’s sudden paralysis during a indoor rock-climbing incident leaves her daughter injured, and House’s new team looking for a cure. Meanwhile, House organizes his new recruits’ Secret Santa gift exchange… with a few twists of his own.
When an infant suffers breathing trouble and liver failure, House and the team must look at the medical history of the mother in order to find an answer, and ultimately land on a discovery that forces the mother to jeopardize not only her child’s health but her own. Meanwhile Taub and Foreman must find a new female doctor to fill the spot vacated by Thirteen and House and Wilson learn a thing or two about parenting while caring for Cuddy’s daughter.
When a college student collapses after a bout of raucous sex with his girlfriend, Dr. House and his team scramble to figure out why. He’s got too many symptoms to add up to just one disease and soon his immune system is so perilously compromised a simple cold could kill him. As his condition deteriorates quickly, House needs to think – and get more Vicodin. But when Wilson nags House about his nasty pill habit it proves extremely useful to House, just not in the way Wilson intended.
When an old friend and former patient of Wilson’s exhibits paralysis in his right arm, Wilson puts himself on the case. House wagers Wilson that the patient’s symptoms are attributed to new cancer cells. Wilson accepts even though he is reluctant to believe the cancer has returned. With the help of the team, Wilson works to diagnose the patient more optimistic results, but when things take a turn for the worse, Wilson must address his inability to separate patient from friend. Meanwhile, Cuddy seeks advice in her search for real estate.
A young mother has a seizure while bathing her newborn son and nearly drowns him. House and the team have two cases at one time as they try to save the infant and determine the cause of the mother’s seizures.
After House’s medical license is reinstated, he reclaims his role as Head of Diagnostics in time to treat Hank Hardwick, an adult film star admitted to Princeton Plainsborough for pulsating eye pain. Meanwhile, Cuddy is reminded that Princeton Plainsborough is not conducive to healthy personal relationships.
After recovering from his gunshot wounds, House works feverishly on two cases at the same time: a paralyzed man who drove his wheelchair into a swimming pool and a woman who became paralyzed after a yoga session.
When a teenage lacrosse player is stricken with an unidentifiable brain disease, Dr. House and the team hustle to give his parents answers. Chase breaks the bad news, the kid has MS, but the boy’s night-terror hallucinations disprove the diagnosis and send House and his team back to square one. As the boy’s health deteriorates. House’s side-bet on the paternity of the patient infuriates Dr. Cuddy and the teenager’s parents, but may just pay off in spades.
