House and the team take on the case of a man who starts tearing blood. Meanwhile, House is interviewing for a new favorite hooker, since his current favorite, Emily, has decided to get married and leave the business. Desperate for Emily “companionship,” House teams up with his “wife” Dominika to sabotage Emily’s budding relationship.
A bus accident leaves House with serious head trauma and partial amnesia. He comes to believe that a patient on the bus had a life-threatening disease and struggles to recall who it was, and what they had.
The team takes on the case of a high school senior who inexplicably blacks out during a class field trip. While in the hospital, the patient repeatedly hallucinates. After exhausting myriad ineffective treatments for her mysterious ailments, House attempts one last controversial approach to diagnosing her: monitoring her cognitive patterns and looking for clues. Meanwhile, Taub airs his dirty laundry at work, and Wilson attempts to furnish his condo.
House puts a well-known medical researcher through a battery of tests to determine why he collapsed in his lab. When the team is unable to diagnose the problem, the doctor asks the team to help him end his life. House is forced to use his cane again after the ketamine has worn off as he deals with a clinic patient’s teenaged daughter who has a crush on him.
House treats a 16-year-old chess prodigy who gets everyone on the team annoyed with his behavior. Foreman is upset with House because he thinks his boss sabotaged his job interview with another hospital.
When a nun comes into the clinic with swollen arms, rash and bleeding in her palms, Dr. House’s diagnosis is a bad allergy, not stigmata. However, when he gives her a shot of medication, she has a heart attack, and whether he gave her the correct amount of medicine comes into question. As the the nun’s case unfolds, the team has to deal with questions regarding their own calling, faith and whether or not they can trust the direction in which their mentor is leading them.
A teenage boy attempting to follow in his late father’s footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Meanwhile, House looks for creative ways to remove his ankle monitor so that he can attend a boxing match in Atlantic City, and he treats a patient who is convinced he is suffering from diabetes. Also, Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.
A patient with both male and female DNA has the team stumped. Meanwhile, House starts acting nicely, raising Cuddy’s and Wilson’s suspicions that something is terribly wrong.
When a six-year-old boy is brought in with the same symptoms as another patient who died years ago under House’s care, House believes the cases are identical and he can predict the course of the boy’s illness. Meanwhile, the clinic hosts a poker night to benefit the oncology department.
Princeton-Plainsboro Teaching Hospital is turned upside-down when billionaire entrepreneur Edward Vogler buys his way into becoming Chairman of the Board. Vogler intends to use the hospital as a new biotech venture, meaning they no longer require the financially draining services of one Dr. Gregory House.
Meanwhile, a powerful young woman who seemingly has it all – perfect life, perfect body, perfect job – becomes inexplicably paralyzed. Upon discovering her deadly secret, House finds himself fighting for her life even though it means risking his job and his medical license.
House and the team take on the case of a woman who collapsed in the middle of a cooking class, and they soon learn she is a highly-renowned cancer researcher who recently gave up her entire career in order to pursue her own personal happiness. Though the team struggles to understand how the woman could give up saving lives for the sake of her own contentment, each grapple with the pursuit of happiness (or lack thereof) in their own lives. As the patient’s condition continues to worsen, so does Thirteen’s as she begins to suffer serious and life-threatening reactions to the experimental Huntington’s Disease clinical trial. Meanwhile, Cuddy attempts to make House’s life miserable for him in retaliation for his part in her own unhappiness.
A severely broken arm reveals a bizarre case of bone loss and ends the comeback plans of major league pitcher Hank Wiggen. House suspects Hank – with a history of drug abuse – is lying about using steroids, as his condition worsens. When Hank’s kidneys start to fail, his wife offers to donate hers, but she would have to abort her early pregnancy. Forced into an impossible solution, and admitting failure as an addict, Hank tries to take his own life. House and his team must isolate and fix the problem soon if this pitcher’s life, as well his career, can be saved.
An ailing man suffers from blackouts and sleepwalks, leading the team to wonder if his sleepwalking is a symptom, or how the man is becoming exposed to something else. When the man’s daughter grows ill as well, the team must provide a diagnosis before both die. Meanwhile, Cuddy adopts a newborn but when the birth mother displays a rash, she has to make a decision between putting the mother or daughter at risk.
House and the team try to diagnose a man living with severe, chronic pain; Thirteen and Foreman explore their complicated relationship; Cuddy discovers that caring for her baby leaves her with little time to run the hospital.
House and the team take on the case of a woman Julia, who is in an open marriage and becomes ill during a date with her on-the-side boyfriend. As perplexing as the case is, Julia’s happy and healthy, yet polygamous relationship is equally baffling to the team. Meanwhile, House tests Wilson’s relationship with Sam.
In the aftermath of personal tragedy, Wilson resigns from the hospital… and from his friendship with House. Meanwhile, Thirteen struggles with her personal medical problems while helping treat an executive assistant with a similar situation to her own.
The team treats an Army veteran charged with treason after he leaked classified information. But the patient’s life is put at risk when he refuses treatment unless he and his brother are given information about their late father, a war veteran, which raises questions about loyalty to one’s family and country. Meanwhile, Adams suspects House may be sick, so she recruits Wilson and the other team members to plan an intervention and investigate his illness.
When a waitress with a perfect memory suffers temporary paralysis, her older sister visits her in the hospital, which triggers high stress levels and even more health complications.
Just before mobster Joey Arnello spills the beans in federal court and enters witness protection, he collapses. Is he faking? A court order instructs House to find out – and fast. House and his team struggle to diagnose and cure Joey while Joey’s brother Bill tries to slow things down and keep Joey from testifying.
Meanwhile, Cuddy struggles to convince Vogler that House is an essential part of the hospital. With Joey mysteriously slipping in and out of a coma, and House’s job on the line, House makes an exception to his own policy and gets to know his patient.
A gay man with full-blown AIDS collapses in front of House’s home and goes into shock. When House discovers the man’s father is suffering from symptoms of his own, he must determine if they might be connected and save both their lives. Meanwhile, Cameron faces a potentially life-threatening disease of her own.
