House and the team treat a young boy who claims there is a tracking device in his neck and believes he has been the subject of alien experimentation. Cameron is outraged when she learns Cuddy and Wilson have been lying to House about the diagnosis on his last case.
When an obese 10-year-old girl presents with a heart attack, House and his team investigate. At first thinking it’s an adverse reaction to diet pills, they ultimately uncover a much more deadly source of her illness.
Meanwhile, under pressure from hospital management, House tries to figure out which of his team to fire. But once he makes a decision, Vogler doesn’t accept it and demands he pick someone else, leading House to suspect one of his team members is giving inside information to Vogler.
After losing a bet with Wilson over a boxing match, House is convinced that his fighter has an underlying medical condition that cost him the fight. While he tries to prove it, he leaves his team alone to help a bomb scientist who suffered a seizure. Meanwhile, House may be experimenting with a new drug to help his leg pain.
When it appears that Lucy Palermo, a schizophrenic mom with deadly deep vein thrombosis, is lying about her alcohol intake, Dr. House is the lone voice of reason. Under the scrutiny of her hyper-vigilant teenage son, House takes Lucy off all her medication and secretly sends Foreman and Chase to search her apartment for clues. An anonymous call to Social Services makes House question whether Lucy is really schizophrenic, and causes Lucy’s son, Lucas, to blame Dr. House for making the call. Wading through Lucy’s altered reality to get to the truth and save her life, House discovers it isn’t mom who’s keeping the secrets and reality isn’t always what it seems.
A seemingly healthy 14-year-old girl collapses during a skateboarding exhibition; House and Cuddy face the challenge of handling their romantic relationship at work.
A Cuban couple attempt to get to America by raft… to see House about the wife’s heart condition. But when she gets worse House wonders if someone on his staff messed up. Meanwhile Foreman prepares to leave and his departure threatens to shake up the entire team.
House and his team are placed under review after a staff member gets hurt.
In the aftermath of the bus accident, House struggles with his head injuries and short-term memory loss, and must deal with a concerned Wilson who believes his friend’s health may be in danger.
House and the team try to link symptoms of a teenage military recruit and his drill sergeant while. House secretly helps Cuddy’s daughter get into a prestigious preschool. Someone posted a disparaging photo of Chase on a social-networking site.
While a severely burned teenager is admitted and his blood tests come back with strange results, House makes himself the guinea pig in his own unofficial tests of a new drug designed to treat migraines to prove a former medical school colleague is wrong about the drug.
During a day in the life of Princeton Plainsboro’s Dean of Medicine, Dr. Lisa Cuddy, the inner workings of the hospital are seen through her eyes. This day proves to be especially trying as Cuddy wrestles with myriad hospital issues and staff disputes that test her perseverance and skills as an administrator, all while juggling issues in her personal life.
The team encounters logistical problems while trying to run tests on a 600-pound man due to his extremely large size. Meanwhile, House spends the night in jail after being arrested by Detective Tritter for various charges, including resisting arrest.
Cuddy decides to spend more time at home to take care of her newly adopted baby and passes some of her day-to-day responsibilities off to Cameron, including supervising House. Cameron is forced to play House’s games and becomes involved in a power struggle as he and the team take on the case of a Special Education teacher who collapsed after spitting up blood in the middle of class. As House tests Cameron’s tolerance for his extreme measures, the patient continues to fall ill and House insists the teacher’s seemingly inherent goodness is actually a pathology.
With his diagnostic team gone, House tries to diagnose a young woman who survived an office building collapse. With the condition getting worse, Cuddy puts pressure on House to hire a new team, but instead attempts a differential diagnosis with help from the janitor.
House and Chase find themselves in a serious situation after a young mother with stomach pains dies. Months later, Stacy counsels Chase prior to his disciplinary hearing, and must determine whether Chase made a mistake that ultimately led to the patient’s death. She soon realizes he is holding something back.
A famous celebrity photographer suffers from a stroke while being pregnant at her early forties. House and his team have to deal with a great dilemma, save the mother or her unborn child.
When a controversial African politician falls ill, he is brought to Princeton Plainsboro for treatment. The team struggles with whether to help a merciless dictator being subpoenaed for crimes against humanity in his country. Meanwhile, Wilson tries to make peace with a feuding neighbor, but House’s prying exacerbates the problem.
Dr. Foreman believes an uncooperative homeless woman is faking seizures to get a meal ticket at the teaching hospital. But her homelessness strikes a personal chord with Dr. Wilson and he grows determined to keep her from falling between the cracks. Her worsening symptoms prove to be a complex mystery for House and his team, but the mystery of her identity and medical history may hold the answers to saving her life. Just as the team suspects she has contagious meningitis, the woman goes missing, only to be Tasered by the police, who bring her back. But House deduces the Taser may have proven yet another diagnosis, with dire results.
A CEO falls mysteriously ill just days before he signs a contract that would relocate his company’s entire labor force to China. House attempts to make an underhanded business transaction with his wealthy patient, but when the patient’s condition worsens, the team must work around the clock to save his life. Meanwhile, Park prepares for her hearing with the Princeton Plainsboro Disciplinary Committee chaired by Foreman, and Adams’ outlook on her patient’s business venture reveals her deeper feelings about loyalty.
A dying patient insists that he has the same disease affecting his heart that killed his father and grandfather at the age of 40. Meanwhile, House discovers that he has a hearing problem while trying to duck student rounds.
