Due to a political conspiracy, an innocent man is sent to death row and his only hope is his brother, who makes it his mission to deliberately get himself sent to the same prison in order to break the both of them out, from the inside out.
After taking delivery of a package from The Company, Lincoln realizes that they are deadly serious. Michael’s new break out plan relies on electricity. Haywire is back from the dead, haunting disoriented Mahone. Bellick and T-Bag get special attention from Lechero.
Michael finds out a storeroom fundamental to his escape plans has been converted into a break room. Veronica and Nick are being threatened.
Michael and Lincoln are eager to locate the Double K ranch where Westmoreland hid his millions. Sucre goes to Las Vegas to prevent Maricruz from marrying his cousin Hector. C-Note gets on a train. Mahone is given an important package.
C-Note gets into a tricky situation when a robber holds up the diner he is in and demands every-one into the storage room until the police arrive.Michael, Lincoln and Kellerman get closer to revealing the conspiracy with the help of Sarah.Mahone finds a new ally in Bellick.
An unlikely alliance forms between Bellick and Sucre while Michael is determined to face the president. T-Bag gets into some trouble when he loses his luggage and C-Note faces major consequences after some of his actions.
Wyatt gets a taste of his own medicine, and Mahone finds some resolution. T-Bag scrambles when the police investigate his missing co-worker while Gretchen gets cozy with a Company man. Meanwhile, Michael’s condition continues to worsen, and a team member makes the ultimate sacrifice while planning the underground break-in for Scylla.
Michael, Lincoln and Sucre must crash a police benefit to obtain the next card key. Reeling from another death, Sarah falls back into an old habit. T-Bag arouses suspicion and runs into some old “friends” his first day on the job.
Michael, Whistler, and Mahone make their break from Sona. But Mahone seems like the odd man out along the way.
The Panamanian Army arranges Michael to get a taste of solitary. T-Bag reserves a spot in the escape. Bellick’s life turns into an uphill battle. Susan traps Sucre.
Michael tries to bring down the Company once and for all.
As Lincoln is about to be executed, he briefly sees his father in the viewing room. A phone call from judge Kessler delays the execution. After reviewing the newly surfaced evidence, the judge orders the exhumation of Steadman’s body.
Michael creates a new, more dangerous, break-out plan, involving going through the prison yard. An accident puts Michael’s new plan in danger.
The day has finally come for Sara’s trial while critical information that will exonerate her is being debunked. Meanwhile, Michael is determined to get his hands on the 5 million and to stop T-Bag’s reign of terror. Bellick is also money hungry and will do whatever it takes to hunt down T-Bag. Kellerman decides his fate while Lincoln and Mahone square off.
Lincoln takes members of the team to Las Vegas where Sucre gets an indecent proposal. Sarah learns about Michael’s condition, and Roland pushes his luck too far. Gretchen teams up with T-Bag who makes an offer to Michael he cannot refuse. Meanwhile, the secrets in Whistler’s bird book are finally revealed.
Mahone takes an interest in the story of DB Cooper.In their quest to find Westmoreland’s treasure, Michael and Lincoln travel house-to-house in Utah. Haywire’s journey outside the prison walls continues. Sucre bumps into an acquaintance.
Michael and a wounded Lincoln try to outmaneuver Mahone, who is hot on their trail. Sara gets a surprise visit to her bedside.Following his suspension, Bellick recruits a resolute partner to aid in his quest to get the escapees behind the bars.Sucre and C-Note head out for their family reunions-regardless of being observed by the authorities.
A new inmate named Tyge is brought to Sona. After he seemingly recognizes Whistler, Michael’s doubts arise. T-Bag enters a new area of commerce.Lincoln goes to the seaside with Sofia. Sucre takes over the side-business of his predecessor.
Michael must get the key to the infirmary and enlist the help of an old face, while Lincoln learns the identity of his kidnapper and another inmate learns of the escape.
Michael, whose condition is deteriorating, winds up in the hands of The Company who promise Lincoln that they can save Michael’s life in exchange for a favor. Elsewhere, Gretchen and Self wind up with Scylla and a buyer.
Michael is forced to give up Fibonacci’s location to Philly Falzone, and Kellerman and Hale get a little unwanted help to track down LJ who has gone missing. Veronica and Nick uncover evidence against the man Lincoln was convicted of murdering.
